{"id":169,"date":"2021-05-24T19:04:32","date_gmt":"2021-05-24T23:04:32","guid":{"rendered":"http:\/\/herpescureadvocacy.com\/?p=169"},"modified":"2021-05-26T23:39:47","modified_gmt":"2021-05-27T03:39:47","slug":"what-is-the-timeline-for-a-herpes-cure","status":"publish","type":"post","link":"https:\/\/herpescureadvocacy.com\/2021\/05\/24\/what-is-the-timeline-for-a-herpes-cure\/","title":{"rendered":"What is the timeline for a Herpes Cure?"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"563\" data-attachment-id=\"168\" data-permalink=\"https:\/\/herpescureadvocacy.com\/2021\/05\/24\/what-is-the-timeline-for-a-herpes-cure\/winter-view\/\" data-orig-file=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/05\/winter-view.jpg?fit=2365%2C1774&amp;ssl=1\" data-orig-size=\"2365,1774\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"winter-view\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/05\/winter-view.jpg?fit=750%2C563&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/05\/winter-view.jpg?resize=750%2C563&#038;ssl=1\" alt=\"\" class=\"wp-image-168\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The most frequently asked question in our community?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What is the <strong>timeline<\/strong> for a Herpes Cure?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">When will there be a herpes cure? There have always been companies working towards better treatments, vaccines, and cures for HSV-1 and HSV-2, and many have failed. But recently two events changed the possible timeline for a Herpes cure significantly:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In 2012, CRISPR was discovered by a group of scientists, namely Dr. Jennifer Doudna. CRISPR reduced the time and cost in gene editing by over 99%. Only 5 years later, the FDA approved the first gene therapy on the market called Luxturna, which partially cures a rare, but horrible eye disease that results in blindness. Today, we now have 3 organizations (Shanghai BDgene, Excision BioTherapeutics, and Fred Hutch Cancer Research Center) using gene editing to actually cure Herpes Simplex Virus.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In 2017, the therapeutic vaccine for herpes zoster, Shingrix, was approved by the FDA unanimously. This vaccine was significant in a number of ways. Firstly, it has the highest efficacy rating out of any therapeutic vaccine ever developed with a 91-97% efficacy in preventing zoster outbreaks for over 4.5 years after one 2-dose regiment. Secondly, the vaccine is a subunit vaccine, which typically are not as effective for therapeutic applications. However, the reason Shingrix in particular is a highly effective subunit vaccine was due to the adjuvant used. An adjuvant assists in boosting the immune response to a virus. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This why Shingrix is much more effective than the previous therapeutic vaccine for herpes zoster, Zostavax, which is live-attenuated and only has a 50-60% efficacy. The Sanofi Pasteur trials, for example, are utilizing an adjuvant for their 4 vaccines being tested for Herpes Simplex Virus, HSV-2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Given these two developments in the past 10 years, it is only a matter of time before an effective therapeutic herpes cure, vaccine or gene therapy is released on the market. In terms of when exactly, either one will make it to market is harder to say.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If we look at how long the Shingrix vaccine was in trials, it lasted from Phase I in 2008 to FDA approval in 2017, so a total of 9 years. If the Sanofi Pasteur trials follow a similar trend, we&#8217;ll see their HSV-2 therapeutic vaccine on the market around 2029. In email communication with X-Vax last year, they indicated plans to begin Herpes cure clinical trials in 2022 and anticipated that trials will last about 7-10 years before being released on the market, so assuming 7-10 years from Phase I to market is reasonable.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The closest new treatments coming to market, however, would be a monoclonal antibody treatment (from either <strong>Heidelberg Therapeutics<\/strong> or <strong>United BioPharma<\/strong> both of which are in Phase 2 trials), 2nd a new more effective antiviral Pritelivir from <strong>AiCuris<\/strong> (currently in Phase 3 trials), or 3rd a new immunotherapy SADBE from <strong>Squarex<\/strong> (currently planned for Phase 3). All of which are estimated to hit the market in 2025. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Time flies, so we have to both be patient and advocate for a Herpes cure urgently.<\/p>\n\n\n\n<hr class=\"wp-block-separator\" \/>\n\n\n\n<h2 class=\"wp-block-heading\">Learn more about the <strong>timeline<\/strong> for Herpes cure&#8230;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Stay in touch. Join our community. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Help us fight for a cure now. <a href=\"https:\/\/herpescureadvocacy.com\/contact\/\">Contact us.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The most frequently asked question in our community? What is the timeline for a Herpes Cure? When will there be a herpes cure? There have always been companies working towards<a class=\"more-link\" href=\"https:\/\/herpescureadvocacy.com\/2021\/05\/24\/what-is-the-timeline-for-a-herpes-cure\/\">Continue reading <span class=\"screen-reader-text\">&#8220;What is the timeline for a Herpes Cure?&#8221;<\/span><\/a><\/p>\n","protected":false},"author":205069572,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1],"tags":[719338643,103],"class_list":["post-169","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-advocacy","tag-news","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is the timeline for a Herpes Cure? - Herpes Cure Advocacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/herpescureadvocacy.com\/2021\/05\/24\/what-is-the-timeline-for-a-herpes-cure\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is the timeline for a Herpes Cure? - Herpes Cure Advocacy\" \/>\n<meta property=\"og:description\" content=\"The most frequently asked question in our community? 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The company has stated that they plan to begin clinical trials in Q1 2023. Excision's cutting edge CRISPR gene therapy platform is built on technology\u2026","rel":"","context":"In \"Crispr\"","block_context":{"text":"Crispr","link":"https:\/\/herpescureadvocacy.com\/tag\/crispr\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/zlsw0sxxthsrkxriicdt_dsc_0345.jpg?fit=1200%2C797&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/zlsw0sxxthsrkxriicdt_dsc_0345.jpg?fit=1200%2C797&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/zlsw0sxxthsrkxriicdt_dsc_0345.jpg?fit=1200%2C797&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/zlsw0sxxthsrkxriicdt_dsc_0345.jpg?fit=1200%2C797&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/zlsw0sxxthsrkxriicdt_dsc_0345.jpg?fit=1200%2C797&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":6126,"url":"https:\/\/herpescureadvocacy.com\/2025\/07\/26\/crispr-and-herpes\/","url_meta":{"origin":169,"position":1},"title":"CRISPR and Herpes","author":"Patient Advocate","date":"July 26, 2025","format":false,"excerpt":"A tool to edit herpes out of the genome. Clustered Regularly Interspaced Short Palindromic Repeats CRISPR is an exciting new tool that scientists have used to edit genomes. It was discovered that different bacteria use CRISPR to defend themselves against viral infections, and we have now adopted similar techniques for\u2026","rel":"","context":"In &quot;Herpes Cure Research&quot;","block_context":{"text":"Herpes Cure Research","link":"https:\/\/herpescureadvocacy.com\/category\/herpes-cure\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/10\/pexels-photo-4033152.jpg?fit=1200%2C800&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/10\/pexels-photo-4033152.jpg?fit=1200%2C800&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/10\/pexels-photo-4033152.jpg?fit=1200%2C800&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/10\/pexels-photo-4033152.jpg?fit=1200%2C800&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/10\/pexels-photo-4033152.jpg?fit=1200%2C800&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":2277,"url":"https:\/\/herpescureadvocacy.com\/2023\/05\/10\/herpes-keratitis-cure-advances-to-phase-3-clinical-trials-in-china\/","url_meta":{"origin":169,"position":2},"title":"Herpes Keratitis Cure advances to Phase 3 Clinical Trials in China","author":"Patient Advocate","date":"May 10, 2023","format":false,"excerpt":"BDGene Therapeutics is a Chinese biotech company based in Shanghai. BDgene now has approval to run Phase 3 trials (held in China) on their gene therapy cure for HSV-1 keratitis. The gene editing treatment for viral keratitis (BD111), developed based on BDmRNA delivery patent technology, has completed 3 human clinical\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"shallow focus photography of human eyes","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/05\/pexels-photo-834783.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/05\/pexels-photo-834783.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/05\/pexels-photo-834783.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/05\/pexels-photo-834783.jpeg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/05\/pexels-photo-834783.jpeg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/05\/pexels-photo-834783.jpeg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":1297,"url":"https:\/\/herpescureadvocacy.com\/2022\/06\/29\/possible-herpes-keratitis-cure-takes-another-step-bdgene-of-china-applies-for-orphan-drug-designation-at-the-fda\/","url_meta":{"origin":169,"position":3},"title":"Possible herpes keratitis cure takes another step: BDGene of China applies for Orphan Drug Designation at the FDA","author":"Patient Advocate","date":"June 29, 2022","format":false,"excerpt":"Chinese company BDGene from Shanghai continues to lead in the global race for a herpes keratitis cure. The highly anticipated treatment, BD111 has reached a big milestone as it applied for Orphan Drug designation from the US FDA. Previously, BD111 has received international attention for its progress with a gene\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/06\/pexels-photo-4033148.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/06\/pexels-photo-4033148.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/06\/pexels-photo-4033148.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/06\/pexels-photo-4033148.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/06\/pexels-photo-4033148.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/06\/pexels-photo-4033148.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":239,"url":"https:\/\/herpescureadvocacy.com\/2021\/05\/20\/current-herpes-cure-research-at-fred-hutch-cancer-center\/","url_meta":{"origin":169,"position":4},"title":"Current Herpes Cure Research at Fred Hutch Cancer Center","author":"Patient Advocate","date":"May 20, 2021","format":false,"excerpt":"The reason Herpes Cure Advocacy was born, the Herpes Simplex Virus cure research at the Jerome Lab at Fred Hutch Cancer Center provides great hope. Research at The Jerome Lab is on a sterilizing cure, developing a gene therapy to fully eradicate HSV-1 and HSV-2. So far, Dr. Keith Jerome\u2026","rel":"","context":"With 2 comments","block_context":{"text":"With 2 comments","link":"https:\/\/herpescureadvocacy.com\/2021\/05\/20\/current-herpes-cure-research-at-fred-hutch-cancer-center\/#comments"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":5,"url":"https:\/\/herpescureadvocacy.com\/2021\/04\/18\/herpes-cure-vaccine-research\/","url_meta":{"origin":169,"position":5},"title":"Latest Herpes Cure Research Projects","author":"Patient Advocate","date":"April 18, 2021","format":false,"excerpt":"Updated as of 4\/18\/21. These are herpes cure research projects, of which we are aware, that are either in clinical trials currently or have expressed intent. For the latest timelines, news, videos, and dialogue on Herpes (HSV) cure research projects please join the Herpes Cure Research Reddit group. 1. The\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/04\/img_5393.jpg?fit=1100%2C832&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/04\/img_5393.jpg?fit=1100%2C832&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/04\/img_5393.jpg?fit=1100%2C832&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/04\/img_5393.jpg?fit=1100%2C832&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/04\/img_5393.jpg?fit=1100%2C832&ssl=1&resize=1050%2C600 3x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/posts\/169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/users\/205069572"}],"replies":[{"embeddable":true,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/comments?post=169"}],"version-history":[{"count":5,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/posts\/169\/revisions"}],"predecessor-version":[{"id":174,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/posts\/169\/revisions\/174"}],"wp:attachment":[{"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/media?parent=169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/categories?post=169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/tags?post=169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}