{"id":3428,"date":"2024-04-01T18:43:38","date_gmt":"2024-04-01T22:43:38","guid":{"rendered":"https:\/\/herpescureadvocacy.com\/?p=3428"},"modified":"2024-04-02T16:37:44","modified_gmt":"2024-04-02T20:37:44","slug":"getting-a-better-grasp-on-genital-hsv-1","status":"publish","type":"post","link":"https:\/\/herpescureadvocacy.com\/2024\/04\/01\/getting-a-better-grasp-on-genital-hsv-1\/","title":{"rendered":"Getting a Better Grasp on Genital HSV-1"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"462\" data-attachment-id=\"3443\" data-permalink=\"https:\/\/herpescureadvocacy.com\/2024\/04\/01\/getting-a-better-grasp-on-genital-hsv-1\/structure-of-herpes-simplex-virus-1-hsv-1\/\" data-orig-file=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Structure-of-Herpes-simplex-virus-1-HSV-1.webp?fit=1200%2C740&amp;ssl=1\" data-orig-size=\"1200,740\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Structure-of-Herpes-simplex-virus-1-HSV-1\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Structure-of-Herpes-simplex-virus-1-HSV-1.webp?fit=750%2C462&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Structure-of-Herpes-simplex-virus-1-HSV-1.webp?resize=750%2C462&#038;ssl=1\" alt=\"\" class=\"wp-image-3443\" srcset=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Structure-of-Herpes-simplex-virus-1-HSV-1.webp?resize=1024%2C631&amp;ssl=1 1024w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Structure-of-Herpes-simplex-virus-1-HSV-1.webp?resize=300%2C185&amp;ssl=1 300w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Structure-of-Herpes-simplex-virus-1-HSV-1.webp?resize=768%2C474&amp;ssl=1 768w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Structure-of-Herpes-simplex-virus-1-HSV-1.webp?w=1200&amp;ssl=1 1200w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One current challenge in the field of genital herpes is improving the diagnosis and management of patients with genital infections caused by herpes simplex type 1 (HSV-1).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While HSV-1 and -2 are closely related, they differ in important ways. Perhaps most notably, up until now HSV-2 has overwhelmingly been the more prevalent cause of genital herpes infections. Accordingly, researchers and clinical experts have spent a great deal more time and resources studying HSV-2\u2014looking at everything from natural history to diagnostic tools to drug development.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the last two decades, however, the field has seen a marked increase in the number of genital herpes cases caused by HSV-1. Previously HSV-1 was associated almost entirely with oral-facial herpes, but by the end of the 1990s a significant percentage of new genital herpes diagnoses were being identified as HSV-1 cases. According to Dr. Christine Johnston, MD, of the University of Washington (UW), modeling studies show that by 2050 an increasing proportion of HSV-1 infections will be acquired sexually\u2014a change that will largely affect adolescents and young adults. \u201cHistorically, HSV-1 had been acquired in childhood or adolescence,\u201d says Johnston. \u201cBut now we\u2019re having less acquisition during this period and people are getting their first exposure to HSV-1 when they initiate sexual activity.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Johnston and her colleagues, including staff at the UW Virology Research Clinic, have been tracking HSV-1\u2019s changing epidemiology and have published a number of related papers. Speaking to a webinar hosted by Herpes Cure Advocacy in March, Johnston outlined the many areas in which scientists are seeking new empirical data on genital HSV-1. This research has touched on clinical management, immunology studies, behavioral impacts, and more.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For a study published in JAMA in 2022, Johnston\u2019s group enrolled 82 subjects who had no prior herpes symptoms but were found to be genital HSV-1 positive by viral culture or polymerase chain reaction (PCR). Researchers then had these subjects collect genital and oral swabs daily for months 2 and 3 after the first episode and again for months 11 and 12. Patients also completed diaries to collect additional information.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">About half of the subjects had a documented \u201cprimary episode,\u201d meaning a newly acquired HSV infection with no evidence of prior HSV antibodies. The other half was considered to have a \u201cnonprimary first episode,\u201d meaning that they had previously acquired herpes and therefore had some degree of immune protection.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This distinction turned out to be a critical factor in the results of Johnston\u2019s study. Her team found that genital HSV-1 subjects in the \u201cprimary episode\u201d category had significantly greater disease burden than non-primary subjects, with more lesions and higher rates of viral shedding.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study found viral shedding at both genital and oral sites. Shedding frequency from the genital area was 12% of days in the month 2-3 data, and fell to 7% at month 11-12. Oral shedding, meanwhile, remained steady at roughly 4% to 5% of days through both sessions. With both genital and oral shedding, rates were higher for subjects presenting with a true primary.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cOn average, recurrences are less frequent for HSV-1 compared to HSV-2,\u201d says Johnston.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWith HSV-1, people will have median of 1 recurrence in first year, a figure that falls somewhere between zero and 1 after that first year.\u201d With genital HSV-2, historical studies would project the average number of recurrences at 5 in year 1, with a likely steady decline over time.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Overall, comparing the lab results for the 82 HSV-1 patients with historical data on people with genital HSV-2, the HSV-1 group in Johnston\u2019s study experienced fewer lesions and lower rates of viral shedding.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Johnston believes more studies are needed to sort out some of the clinical challenges to HSV-1, pointing to the need for better serologic tests, a better understanding of the role of antiviral treatment in genital HSV-1, and more data on ways to reduce transmission risk to partners.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8211; Charles Ebel<\/p>\n\n\n\n<p class=\"coblocks-animate wp-block-paragraph\" data-coblocks-animation=\"slideInLeft\">The <strong>full slide deck<\/strong> for Dr. Christine Johnson\u2019s webinar presentation is available <strong><a href=\"https:\/\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Johnston_HCA_2024.pptx\">here<\/a>,<\/strong> including answers to several frequently asked patient questions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>One current challenge in the field of genital herpes is improving the diagnosis and management of patients with genital infections caused by herpes simplex type 1 (HSV-1). While HSV-1 and<a class=\"more-link\" href=\"https:\/\/herpescureadvocacy.com\/2024\/04\/01\/getting-a-better-grasp-on-genital-hsv-1\/\">Continue reading <span class=\"screen-reader-text\">&#8220;Getting a Better Grasp on Genital HSV-1&#8221;<\/span><\/a><\/p>\n","protected":false},"author":205069572,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-3428","post","type-post","status-publish","format-standard","hentry","category-uncategorized","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Getting a Better Grasp on Genital HSV-1 - Herpes Cure Advocacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/herpescureadvocacy.com\/2024\/04\/01\/getting-a-better-grasp-on-genital-hsv-1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Getting a Better Grasp on Genital HSV-1 - Herpes Cure Advocacy\" \/>\n<meta property=\"og:description\" content=\"One current challenge in the field of genital herpes is improving the diagnosis and management of patients with genital infections caused by herpes simplex type 1 (HSV-1). 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Batteiger, MD, MS, Cornelis A. Rietmeijer, MD, PhD KEYWORDS Herpes simplex virus (HSV), HSV diagnosis, HSV treatment, HSV counseling KEY POINTS \u0015 \u00a0Genital herpes is a very common sexually transmitted infection caused by herpes simplex virus (HSV)-1 or HSV-2. \u0015 \u00a0Counseling is an important aspect of the management\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Services_primary-care-jpeg.webp?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Services_primary-care-jpeg.webp?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Services_primary-care-jpeg.webp?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/04\/Services_primary-care-jpeg.webp?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":3336,"url":"https:\/\/herpescureadvocacy.com\/2024\/02\/22\/hca-welcomes-dr-christine-johnson\/","url_meta":{"origin":3428,"position":1},"title":"HCA Welcomes Dr. Christine Johnston","author":"Patient Advocate","date":"February 22, 2024","format":false,"excerpt":"Talk and Q&A with Dr. Christine Johnston: Genital HSV-1 Infection: New and\u00a0Emerging Research Did you know genital HSV-1 is the fastest growing type of genital herpes?Dr. Christine Johnston will give us an update on genital HSV-1 infections including results from a recent large study of the natural history of genital\u2026","rel":"","context":"With 3 comments","block_context":{"text":"With 3 comments","link":"https:\/\/herpescureadvocacy.com\/2024\/02\/22\/hca-welcomes-dr-christine-johnson\/#comments"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/02\/health-3-2-1.png?fit=1080%2C1080&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/02\/health-3-2-1.png?fit=1080%2C1080&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/02\/health-3-2-1.png?fit=1080%2C1080&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/02\/health-3-2-1.png?fit=1080%2C1080&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/02\/health-3-2-1.png?fit=1080%2C1080&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":261,"url":"https:\/\/herpescureadvocacy.com\/2021\/07\/08\/herpes-is-not-benign-nine-health-complications-linked-to-hsv\/","url_meta":{"origin":3428,"position":2},"title":"Herpes is not Benign: Nine health complications linked to HSV","author":"Patient Advocate","date":"July 8, 2021","format":false,"excerpt":"This post is for anyone supporting the narrative about Herpes Simplex Virus that \u201cit\u2019s not a big deal\u201d. 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