{"id":4168,"date":"2024-07-24T08:05:01","date_gmt":"2024-07-24T12:05:01","guid":{"rendered":"https:\/\/herpescureadvocacy.com\/?p=4168"},"modified":"2024-07-24T08:10:18","modified_gmt":"2024-07-24T12:10:18","slug":"impressions-from-ihw-2024","status":"publish","type":"post","link":"https:\/\/herpescureadvocacy.com\/2024\/07\/24\/impressions-from-ihw-2024\/","title":{"rendered":"Impressions from IHW 2024"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"981\" data-attachment-id=\"4172\" data-permalink=\"https:\/\/herpescureadvocacy.com\/2024\/07\/24\/impressions-from-ihw-2024\/screenshot-2024-07-24-075548\/\" data-orig-file=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/07\/Screenshot-2024-07-24-075548.png?fit=1118%2C1462&amp;ssl=1\" data-orig-size=\"1118,1462\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Screenshot 2024-07-24 075548\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/07\/Screenshot-2024-07-24-075548.png?fit=750%2C981&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/07\/Screenshot-2024-07-24-075548.png?resize=750%2C981&#038;ssl=1\" alt=\"\" class=\"wp-image-4172\" style=\"width:320px;height:auto\" srcset=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/07\/Screenshot-2024-07-24-075548.png?resize=783%2C1024&amp;ssl=1 783w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/07\/Screenshot-2024-07-24-075548.png?resize=229%2C300&amp;ssl=1 229w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/07\/Screenshot-2024-07-24-075548.png?resize=768%2C1004&amp;ssl=1 768w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2024\/07\/Screenshot-2024-07-24-075548.png?w=1118&amp;ssl=1 1118w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>This year\u2019s conference highlighted several innovative studies focusing on interventions and antivirals targeting Herpes Simplex Viruses (HSV). Below, we summarize the key findings and their potential impacts on the treatment of HSV infections.<\/em><\/p>\n\n\n\n<h6 class=\"wp-block-heading\">Gene Editing Therapy for HSV<\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most promising developments presented was a gene editing therapy aimed at curing HSV infections. Researchers at the Fred Hutchinson Cancer Research Center demonstrated that HSV-specific meganucleases delivered by adeno-associated virus (AAV) vectors could eliminate up to 97% of latent HSV DNA from ganglia. This approach not only reduced viral load but also significantly decreased viral shedding in treated mice. The therapy, while generally well tolerated, showed some hepatotoxicity at high doses, highlighting the need for further refinement to enhance its safety profile .<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">Combination Therapy to Prevent Drug Resistance<\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">Another notable study from KU Leuven explored the effects of combination therapy using pritelivir with acyclovir (ACV) or foscarnet (PFA) to prevent HSV-1 drug resistance. The researchers found that these combinations effectively suppressed the evolution of drug resistance in HSV-1, making them promising candidates for future clinical applications. The dual treatment with ACV and pritelivir, in particular, showed no mutations conferring resistance to pritelivir, even after extensive passages under drug pressure .<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">3D Bio-printed Skin Model for Antiviral Screening<\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">A team from Fred Hutch and the University of Washington introduced a novel 3D bio-printed human skin equivalent model to screen for new HSV antivirals. This model, which uses primary human keratinocytes and fibroblasts, enabled the identification of several potent antiviral compounds more effective than acyclovir. Among these were pritelivir and amenamevir, alongside multiple new candidate antivirals. This innovative approach allows for personalized assessments of drug responses, potentially leading to more effective treatments tailored to individual patients .<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">Targeting the Host Proteostasis Network<\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">Research from the Chan Zuckerberg BioHub and the Weizmann Institute of Science focused on the host proteostasis network (PN) as a target for antiviral interventions. By screening compounds that modulate factors involved in protein synthesis and folding, the team identified two compounds with significant anti-HSV1 activity. This host-directed strategy represents a promising new avenue for antiviral development, potentially offering treatments that are less prone to resistance .<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">Inhibition of Stress Hormone Receptors<\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">Virginia Tech researchers investigated the role of stress hormone receptors in HSV-1 reactivation. They found that blocking adrenergic receptors, particularly using beta blockers, reduced the frequency of clinical recurrences of HSV-1 in guinea pigs. This finding suggests that stress hormone receptor inhibitors could be a viable strategy to manage HSV recurrences, providing a new therapeutic option for patients .<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">Targeting HSV Glycoprotein D with Bispecific Antibodies<\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">A team from the University of Pennsylvania explored the use of bispecific antibodies targeting HSV glycoprotein D. This approach aims to expand the therapeutic horizons by enhancing the body\u2019s immune response to the virus. Early results are promising, showing potential for these antibodies to become part of the therapeutic arsenal against HSV .<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">Long-Acting Helicase-Primase Inhibitors<\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">Finally, Assembly Biosciences presented data on ABI-5366, a long-acting helicase-primase inhibitor with potent activity against HSV-1 and HSV-2. This compound showed improved efficacy compared to current nucleoside analogues, demonstrating potential for reducing viral shedding and symptoms in recurrent genital herpes. ABI-5366\u2019s long-acting nature makes it a promising candidate for further clinical development .<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These studies represent significant strides in the fight against HSV, offering hope for effective intervention. I hope this post stimulates discussion and interest in the important work we herpes virologist have dedicated our lives to.<\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">Contributed By Guest Author <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.researchgate.net\/profile\/Brent-Stanfield\">Brent Stanfield, PhD<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Louisiana State University&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">LSU&nbsp;\u00b7&nbsp;Department of Pathobiological Sciences<\/p>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"border-width:1px;grid-template-columns:42% auto\"><figure class=\"wp-block-media-text__media\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"750\" data-attachment-id=\"7143\" data-permalink=\"https:\/\/herpescureadvocacy.com\/?attachment_id=7143\" data-orig-file=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?fit=1080%2C1080&amp;ssl=1\" data-orig-size=\"1080,1080\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Document2\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?fit=750%2C750&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=750%2C750&#038;ssl=1\" alt=\"\" class=\"wp-image-7143 size-full\" srcset=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=1024%2C1024&amp;ssl=1 1024w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=300%2C300&amp;ssl=1 300w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=150%2C150&amp;ssl=1 150w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=768%2C768&amp;ssl=1 768w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=800%2C800&amp;ssl=1 800w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=600%2C600&amp;ssl=1 600w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=400%2C400&amp;ssl=1 400w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=200%2C200&amp;ssl=1 200w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?w=1080&amp;ssl=1 1080w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h6 class=\"wp-block-heading\"><strong><a href=\"https:\/\/herpescureadvocacy.com\/ways-to-give\/herpescureadvocacy.com\/donate\">Give Today and Join the Fight \u2192<\/a><\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Every donation \u2013 whether $10 or $10,000 \u2013 moves us closer to a world where herpes is effectively treated and free from stigma.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Questions about giving?<\/strong>\u00a0Contact us at\u00a0<a href=\"mailto:info@herpescureadvocacy.com\">info@herpescureadvocacy.com<\/a>\u00a0or 302-307-3560.<\/p>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This year\u2019s conference highlighted several innovative studies focusing on interventions and antivirals targeting Herpes Simplex Viruses (HSV). Below, we summarize the key findings and their potential impacts on the treatment<a class=\"more-link\" href=\"https:\/\/herpescureadvocacy.com\/2024\/07\/24\/impressions-from-ihw-2024\/\">Continue reading <span class=\"screen-reader-text\">&#8220;Impressions from IHW 2024&#8221;<\/span><\/a><\/p>\n","protected":false},"author":205069572,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-4168","post","type-post","status-publish","format-standard","hentry","category-uncategorized","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Impressions from IHW 2024 - Herpes Cure Advocacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/herpescureadvocacy.com\/2024\/07\/24\/impressions-from-ihw-2024\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Impressions from IHW 2024 - Herpes Cure Advocacy\" \/>\n<meta property=\"og:description\" content=\"This year\u2019s conference highlighted several innovative studies focusing on interventions and antivirals targeting Herpes Simplex Viruses (HSV). 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Scientists Give Impacted Communities a Voice","author":"Patient Advocate","date":"April 5, 2022","format":false,"excerpt":"The University of Washington Virology Division and the Vaccine and Infectious Disease Division at Fred Hutch Cancer Center have announced a new initiative for members of the communities affected by herpes simplex virus infection to join a new Community Advisory Board that will potentially inform future scientific research and\/or clinical\u2026","rel":"","context":"With 1 comment","block_context":{"text":"With 1 comment","link":"https:\/\/herpescureadvocacy.com\/2022\/04\/05\/hsv-scientists-give-herpes-impacted-communities-a-voice\/#comments"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/04\/pexels-photo-3719037.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2022\/04\/pexels-photo-3719037.jpeg?resize=350%2C200&ssl=1 1x, 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