{"id":4205,"date":"2024-07-28T00:29:44","date_gmt":"2024-07-28T04:29:44","guid":{"rendered":"https:\/\/herpescureadvocacy.com\/?p=4205"},"modified":"2024-07-28T00:32:27","modified_gmt":"2024-07-28T04:32:27","slug":"recap-from-the-alzpi-and-pcom-symposium-bridging-silos-to-accelerate-innovation","status":"publish","type":"post","link":"https:\/\/herpescureadvocacy.com\/2024\/07\/28\/recap-from-the-alzpi-and-pcom-symposium-bridging-silos-to-accelerate-innovation\/","title":{"rendered":"Recap from the AlzPI and PCOM Symposium: Bridging Silos to Accelerate Innovation"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em>The <a href=\"https:\/\/www.alzpi.org\/\" data-type=\"link\" data-id=\"https:\/\/www.alzpi.org\/\">Alzheimer&#8217;s Pathobiome Initiative (AlzPI)<\/a> and <a href=\"https:\/\/www.pcom.edu\/\" data-type=\"link\" data-id=\"https:\/\/www.pcom.edu\/\">The Philadelphia College of Osteopathic Medicine (PCOM)<\/a> hosted a one day symposium, focusing on the research over the last three decades related to microbes and Alzheimer&#8217;s disease (AD). HSV1 was repeatedly included throughout various presentations, showing that this research area of infection and its impact on the brain is critical to continue to explore and elevate<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Starting off the HSV1 and Alzheimer&#8217;s Disease conversation was <a href=\"https:\/\/theconversation.com\/my-work-investigating-the-links-between-viruses-and-alzheimers-disease-was-dismissed-for-years-but-now-the-evidence-is-building-184201\" data-type=\"link\" data-id=\"https:\/\/theconversation.com\/my-work-investigating-the-links-between-viruses-and-alzheimers-disease-was-dismissed-for-years-but-now-the-evidence-is-building-184201\">Dr. Ruth Itzhaki<\/a>, a pioneer in researching the correlation between HSV1 and Alzheimer&#8217;s Disease. Dr. Itzhaki gave an engaging talk on her research and findings. <\/p>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Earlier Work and Correlation Concept of HSV1 and AD<\/summary>\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>HSV1 DNA resides latently but reactivates during stress in the brain of many elderly people. Reactivation damage is presumably limited &amp; localized but the reactivation happens repeatedly &#8211; leading to AD.<\/li>\n\n\n\n<li>HSV1 travels to the brain in late middle age, on decline of the immune system.<\/li>\n\n\n\n<li>There is a genetic component to this that creates a stronger risk of AD when combined with HSV1. APOE-e4 carriers have an increased risk for HSV1 damage to both the Peripheral and Central Nervous Systems. <\/li>\n\n\n\n<li>Over 500 studies, using diverse approaches: epidemiology, molecular and cellular biology, virological methods, etc. all support that HSV1 plays a role in Alzheimer&#8217;s Disease. <\/li>\n<\/ul>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Evidence of HSV1 Reactivation in Living Brain <\/summary>\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>HSV1 DNA detected in brain of HSV positive immunocompromised, but not HSV negative immunocompromised<\/li>\n\n\n\n<li>Systemic infections cause cognitive decline and increased risk of AD. Some vaccines decrease AD risk, however some infections (like COVID), are known to reactivate HSV1.<\/li>\n\n\n\n<li>The risk of Alzheimer&#8217;s Disease is greater in HSV1 infected people than uninfected. Antivirals can help to decrease risk.<\/li>\n\n\n\n<li>There is genetic support that a virus can play a role due to linked pathways that are found between the two.<\/li>\n\n\n\n<li>All of this data supports that there is a causal role for HSV1 in Alzheimer&#8217;s Disease, not just an association. <\/li>\n<\/ul>\n<\/details>\n\n\n\n<p class=\"wp-block-paragraph\">In summary, Dr. Itzhaki answered the two main questions that have driven her research:<strong> <mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-foreground-color\">Is there evidence of reactivation in the brain; and does HSV1 lead to AD? <\/mark><\/strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-foreground-color\">Answer:<\/mark><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-foreground-color\"> <span style=\"text-decoration: underline;\">YES.<\/span> <\/mark><\/strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-foreground-color\">Data in models and in humans both suggest that <\/mark><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-foreground-color\"><span style=\"text-decoration: underline;\">HSV in the brain is pivotal in increasing the risk of Alzheimer&#8217;s Disease. <\/span><\/mark><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Zena Chatila, a PhD Candidate at Columbia University presented on the impact HSV1 has on microglial function and driving immune therapy. Microglia are\u00a0immune cells that patrol the central nervous system (CNS) to respond to damage and pathogens. <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Her work consists of infecting microglia-like cells with HSV1 to study the effects. <\/li>\n\n\n\n<li>The research shows HSV drives microglial memory. Pathogen exposure may rewire functional programming of the microglia through innate immune memory. When exposed to HSV1 as an initial stimulus, a dramatic shift occurs, fundamentally suppressing the response.<\/li>\n\n\n\n<li>She concluded her talk confirming that HSV1 DNA is found in the brain of most elderly people, including those with Alzheimer&#8217;s Disease. <\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading has-normal-font-size\">Why is all of this important?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This is more concrete evidence pointing to the correlation between HSV1 and Alzheimer&#8217;s Disease. This further demonstrates that herpes is not just a benign infection. Herpes can have very serious health outcomes. As more research is dedicated to these effects, along with the research going towards HSV cure and vaccine research, we get closer each day towards developing an effective method to combat HSV.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These conversations are so important to have and to be apart of and it was great to see all of the conversations around Herpes. Advocates are always encouraged to join conferences, lectures, talks, etc. and raise questions around HSV.  If you&#8217;re not sure which events to attend, you can take a look at our <a href=\"https:\/\/herpescureadvocacy.com\/events\/\" data-type=\"link\" data-id=\"https:\/\/herpescureadvocacy.com\/events\/\">Events Calendar<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Thank you to AlzPI and PCOM for hosting a fantastic symposium! A special thank you to all the speakers as well for leading very insightful conversations all around. <\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"border-width:1px;grid-template-columns:42% auto\"><figure class=\"wp-block-media-text__media\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"750\" data-attachment-id=\"7143\" data-permalink=\"https:\/\/herpescureadvocacy.com\/?attachment_id=7143\" data-orig-file=\"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?fit=1080%2C1080&amp;ssl=1\" data-orig-size=\"1080,1080\" data-comments-opened=\"0\" 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https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=300%2C300&amp;ssl=1 300w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=150%2C150&amp;ssl=1 150w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=768%2C768&amp;ssl=1 768w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=800%2C800&amp;ssl=1 800w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=600%2C600&amp;ssl=1 600w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=400%2C400&amp;ssl=1 400w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?resize=200%2C200&amp;ssl=1 200w, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/Document2.png?w=1080&amp;ssl=1 1080w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h6 class=\"wp-block-heading\"><strong><a href=\"https:\/\/herpescureadvocacy.com\/ways-to-give\/herpescureadvocacy.com\/donate\">Give Today and Join the Fight \u2192<\/a><\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Every donation \u2013 whether $10 or $10,000 \u2013 moves us closer to a world where herpes is effectively treated and free from stigma.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Questions about giving?<\/strong>\u00a0Contact us at\u00a0<a href=\"mailto:info@herpescureadvocacy.com\">info@herpescureadvocacy.com<\/a>\u00a0or 302-307-3560.<\/p>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Alzheimer&#8217;s Pathobiome Initiative (AlzPI) and The Philadelphia College of Osteopathic Medicine (PCOM) hosted a one day symposium, focusing on the research over the last three decades related to microbes<a class=\"more-link\" href=\"https:\/\/herpescureadvocacy.com\/2024\/07\/28\/recap-from-the-alzpi-and-pcom-symposium-bridging-silos-to-accelerate-innovation\/\">Continue reading <span class=\"screen-reader-text\">&#8220;Recap from the AlzPI and PCOM Symposium: Bridging Silos to Accelerate Innovation&#8221;<\/span><\/a><\/p>\n","protected":false},"author":205069572,"featured_media":4215,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[719338669],"tags":[],"class_list":["post-4205","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-conference","entry"],"yoast_head":"<!-- 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Alzheimer\u2019s, a progressive neurological disorder, is the most common cause of dementia worldwide, while HSV is best known for causing cold sores and genital\u2026","rel":"","context":"In &quot;Herpes Basics&quot;","block_context":{"text":"Herpes Basics","link":"https:\/\/herpescureadvocacy.com\/category\/article\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":247,"url":"https:\/\/herpescureadvocacy.com\/2021\/07\/03\/herpes-and-alzheimers-link\/","url_meta":{"origin":4205,"position":1},"title":"A Herpes and Alzheimer\u2019s link?","author":"Patient Advocate","date":"July 3, 2021","format":false,"excerpt":"There is mounting evidence that has increasingly pointed to HSV-1 as being possibly involved in Alzheimer's disease. Dr. Itzhaki, who has worked extensively to investigate the link, published a paper in 1991 which was the very first experimental study to link HSV1 and AD. In the paper, she noted that\u2026","rel":"","context":"In \"Advocacy\"","block_context":{"text":"Advocacy","link":"https:\/\/herpescureadvocacy.com\/tag\/advocacy\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":5996,"url":"https:\/\/herpescureadvocacy.com\/2025\/05\/27\/new-gilead-funded-study-supports-hypothesis-that-hsv-1-significantly-increases-alzheimers-disease-risk\/","url_meta":{"origin":4205,"position":2},"title":"2025 Gilead-Funded Study Supports Hypothesis that HSV-1 Significantly Increases Alzheimer\u2019s Disease Risk","author":"Patient Advocate","date":"May 27, 2025","format":false,"excerpt":"Liu\u00a0Y,\u00a0Johnston\u00a0C,\u00a0Jarousse\u00a0N, et al Association between herpes simplex virus type 1 and the risk of Alzheimer\u2019s disease: a retrospective case\u2013control study BMJ Open\u00a02025;15:e093946.\u00a0doi:\u00a010.1136\/bmjopen-2024-093946 Here are our key takeaways from the study \"Association between herpes simplex virus type 1 and the risk of Alzheimer\u2019s disease: a retrospective case\u2013control study\" published in BMJ\u2026","rel":"","context":"In &quot;Herpes Cure Research&quot;","block_context":{"text":"Herpes Cure Research","link":"https:\/\/herpescureadvocacy.com\/category\/herpes-cure\/"},"img":{"alt_text":"men s white dress shirt","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2025\/05\/pexels-photo-356040-e1748491643899.jpeg?fit=400%2C267&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":2749,"url":"https:\/\/herpescureadvocacy.com\/2023\/07\/29\/call-to-action-group-letter-to-president-biden\/","url_meta":{"origin":4205,"position":3},"title":"Call to Action: Group Letter to President Biden","author":"Patient Advocate","date":"July 29, 2023","format":false,"excerpt":"Join hundreds of ID experts, HCPs, and patient advocates in the call for change. The White House 1600 Pennsylvania Avenue NW Washington, DC 20500 July 24, 2023 Dear President Biden, I am writing in support of a federal response to address the cure, treatment, and prevention of Herpes Simplex Virus\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/08\/Group-Letter-Image-1.png?fit=1200%2C1200&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/08\/Group-Letter-Image-1.png?fit=1200%2C1200&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/08\/Group-Letter-Image-1.png?fit=1200%2C1200&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/08\/Group-Letter-Image-1.png?fit=1200%2C1200&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/08\/Group-Letter-Image-1.png?fit=1200%2C1200&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":4361,"url":"https:\/\/herpescureadvocacy.com\/2024\/08\/18\/news-from-herpes-cure-advocacy\/","url_meta":{"origin":4205,"position":4},"title":"News from Herpes Cure Advocacy","author":"Patient Advocate","date":"August 18, 2024","format":false,"excerpt":"There is momentum in the field of new herpes diagnostics and therapies. 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Can infections cause\u2026","rel":"","context":"In &quot;Advocacy&quot;","block_context":{"text":"Advocacy","link":"https:\/\/herpescureadvocacy.com\/category\/advocacy\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/07\/Screenshot-2023-07-15-103920.png?fit=1200%2C794&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/07\/Screenshot-2023-07-15-103920.png?fit=1200%2C794&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/07\/Screenshot-2023-07-15-103920.png?fit=1200%2C794&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/07\/Screenshot-2023-07-15-103920.png?fit=1200%2C794&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/07\/Screenshot-2023-07-15-103920.png?fit=1200%2C794&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":261,"url":"https:\/\/herpescureadvocacy.com\/2021\/07\/08\/herpes-is-not-benign-nine-health-complications-linked-to-hsv\/","url_meta":{"origin":4205,"position":5},"title":"Herpes is not Benign: Nine health complications linked to HSV","author":"Patient Advocate","date":"July 8, 2021","format":false,"excerpt":"This post is for anyone supporting the narrative about Herpes Simplex Virus that \u201cit\u2019s not a big deal\u201d. This is to encourage NIH for more urgency for treatment research, cure, and serology testing. This is to urge the CDC to develop a real prevention strategy including testing and tracking. 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