{"id":4231,"date":"2024-08-03T09:43:26","date_gmt":"2024-08-03T13:43:26","guid":{"rendered":"https:\/\/herpescureadvocacy.com\/?p=4231"},"modified":"2026-03-24T22:47:37","modified_gmt":"2026-03-25T02:47:37","slug":"herpes-impact-on-brain-health-new-study-indicates-shringix-vaccine-prevents-dementia","status":"publish","type":"post","link":"https:\/\/herpescureadvocacy.com\/2024\/08\/03\/herpes-impact-on-brain-health-new-study-indicates-shringix-vaccine-prevents-dementia\/","title":{"rendered":"Herpes Impact on Brain Health: New study indicates Shringix Vaccine prevents dementia"},"content":{"rendered":"\n
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Experts insist we are at a tipping point in scientific research relating to herpesviruses impact on dementia and Alzheimer’s Disease. Last month a new study from a team in Australia indicated that vaccination against Varicella Zoster (VZV) with the Shingles vaccine was found to be preventative against dementia. Read this study to learn more.<\/a> The ground-breaking study speaks to the need for more research in this area also noting the substantial evidence that Herpes Simplex Virus also leads to dementia. An excerpt from the study findings is below. <\/p>\n\n\n\n

The theory that herpes simplex leads to Alzheimer’s and other related dementias is not new – and once considered a fringe theory, is rapidly gaining consensus among experts.<\/p>\n\n\n\n

On a financial reporting call on July 31, 2024, GSK Chief Scientific Officer responded to the study indicating there is similar evidence indicating HSV leads to dementia. An excerpt from the meeting transcript is below. <\/p>\n\n\n\n

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The science is better known, although not by any means comprehensive, for HSV underlying reactivation and therefore inflammation that occurs as a result of that, leading to dementia. <\/em>– GSK Chief Scientific Officer Tony Wood<\/p>\n<\/blockquote>\n\n\n\n

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GSK July 31, 2024 Financial Earnings Report<\/strong><\/h2>\n\n\n\n

Simon Baker (Redburn Atlantic): <\/strong>Thank you very much \u2013 I will limit myself to one question. This is on Arexvy and it is a question for Tony. In terms of the potential mechanism for lower incidence of dementia, I wondered what thoughts you have had on that. There has been some suggestion that it is an indirect effect caused by the vaccine suppressing reactivation of HSV-1 virus. Any thoughts you have on why we are seeing this effect would be much appreciated. Thank you.<\/em><\/p>\n\n\n\n

Tony Wood Chief Scientific Officer at GSK:<\/strong> Simon, I presume you meant Shingrix in that, rather than Arexvy \u2013 that is another story. It is fair to say that there is very little known here, mechanistically, and we are investing in further retrospective studies and mechanistic ones. Let me try to do this quickly. There is some potential that the mechanism may be vascular in nature. It may even be due to, as you say, underlying \u2013 let\u2019s call it subclinical reactivation. The science is better known, although not by any means comprehensive, for HSV underlying reactivation and therefore inflammation that occurs as a result of that, leading to dementia. One can imagine a similar story in the context of shingles or one could even imagine the constant reactivation impacts microglial function. There is a range \u2013 and I haven\u2019t been comprehensive in my answer, to avoid spending too much time on it. It is fair to say that there is a range of different mechanisms. If you want a comprehensive summary, the Australian paper detailing the epidemiological retrospective outcomes has a really nice summary in its concluding paragraph.<\/em><\/p>\n\n\n\n

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NEW STUDY FINDINGS: Herpes zoster vaccination and new diagnoses of dementia: A quasi-randomized study in Australia
<\/strong><\/h6>\n\n\n\n

We believe that our findings call for investments into further research in this area. Ideally, a clinical trial would be conducted to investigate the effect of HZ vaccination on the dementia disease process. However, we also believe that funding research into the mechanisms through which HZ vaccination could affect dementia is an important investment. Several potential mechanisms for this connection have already been recognized. For example, reactivations of the varicella zoster virus have been linked to long-lasting cognitive impairment through vasculopathy (60<\/a>,\u00a061<\/a><\/sup>), amyloid deposition and aggregation of tau proteins (62<\/a><\/sup>), neuroinflammation (63<\/a>\u201366<\/a><\/sup>), as well as cerebrovascular disease resembling that seen in Alzheimer\u2019s disease, including small to large vessel disease, ischemia, infarction, and hemorrhage (67<\/a>,\u00a068<\/a>,\u00a063<\/a>\u201366<\/a><\/sup>). Additionally, there is a substantial body of evidence suggesting that the herpes simplex virus<\/strong> may contribute to the development of dementia (3<\/a>,\u00a04<\/a><\/sup>), along with suggestive evidence that reactivations of the varicella zoster virus may lead to reactivations of the herpes simplex virus<\/strong> in the brain (69<\/a><\/sup>). Lastly, it is conceivable that HZ vaccination affects the dementia disease process through a pathogen-independent immunomodulatory pathway, a hypothesis that has been elaborated recently elsewhere (70<\/a><\/sup>).<\/p>\n\n\n\n

Pomirchy M, Bommer C, Pradella F, Michalik F, Peters R, Geldsetzer P. Herpes zoster vaccination and new diagnoses of dementia: A quasi-randomized study in Australia. medRxiv [Preprint]. 2024 Jun 28:2024.06.27.24309563. doi: 10.1101\/2024.06.27.24309563. PMID: 38978672; PMCID: PMC11230318.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

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Give Today and Join the Fight \u2192<\/a><\/strong><\/h6>\n\n\n\n

Every donation \u2013 whether $10 or $10,000 \u2013 moves us closer to a world where herpes is effectively treated and free from stigma.<\/em><\/p>\n\n\n\n

Questions about giving?<\/strong>\u00a0Contact us at\u00a0info@herpescureadvocacy.com<\/a>\u00a0or 302-307-3560.<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

Experts insist we are at a tipping point in scientific research relating to herpesviruses impact on dementia and Alzheimer’s Disease. 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Alzheimer\u2019s, a progressive neurological disorder, is the most common cause of dementia worldwide, while HSV is best known for causing cold sores and genital\u2026","rel":"","context":"In "Herpes Basics"","block_context":{"text":"Herpes Basics","link":"https:\/\/herpescureadvocacy.com\/category\/article\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":5874,"url":"https:\/\/herpescureadvocacy.com\/2025\/04\/22\/press-updates\/","url_meta":{"origin":4231,"position":1},"title":"Press Updates","author":"Patient Advocate","date":"April 22, 2025","format":false,"excerpt":"Media Inquiries Herpes Cure Advocacy experts are available to speak to the press about ongoing herpes vaccine and cure research, patient advocacy efforts, and herpes diagnosis and treatment. Contact media@herpescureadvocacy.com Herpes Cure Advocacy in the News Press release: Herpes Cure Pipeline 4.0 Notice: HCA Advocates for Neonatal Herpes to be\u2026","rel":"","context":"In "Advocacy"","block_context":{"text":"Advocacy","link":"https:\/\/herpescureadvocacy.com\/category\/advocacy\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2749,"url":"https:\/\/herpescureadvocacy.com\/2023\/07\/29\/call-to-action-group-letter-to-president-biden\/","url_meta":{"origin":4231,"position":2},"title":"Call to Action: Group Letter to President Biden","author":"Patient Advocate","date":"July 29, 2023","format":false,"excerpt":"Join hundreds of ID experts, HCPs, and patient advocates in the call for change. The White House 1600 Pennsylvania Avenue NW Washington, DC 20500 July 24, 2023 Dear President Biden, I am writing in support of a federal response to address the cure, treatment, and prevention of Herpes Simplex Virus\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/08\/Group-Letter-Image-1.png?fit=1200%2C1200&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/08\/Group-Letter-Image-1.png?fit=1200%2C1200&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/08\/Group-Letter-Image-1.png?fit=1200%2C1200&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/08\/Group-Letter-Image-1.png?fit=1200%2C1200&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/08\/Group-Letter-Image-1.png?fit=1200%2C1200&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":261,"url":"https:\/\/herpescureadvocacy.com\/2021\/07\/08\/herpes-is-not-benign-nine-health-complications-linked-to-hsv\/","url_meta":{"origin":4231,"position":3},"title":"Herpes is not Benign: Nine health complications linked to HSV","author":"Patient Advocate","date":"July 8, 2021","format":false,"excerpt":"This post is for anyone supporting the narrative about Herpes Simplex Virus that \u201cit\u2019s not a big deal\u201d. This is to encourage NIH for more urgency for treatment research, cure, and serology testing. This is to urge the CDC to develop a real prevention strategy including testing and tracking. Herpes\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/alejandroescamilla-dude-walkin.jpg?fit=1200%2C1009&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/alejandroescamilla-dude-walkin.jpg?fit=1200%2C1009&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/alejandroescamilla-dude-walkin.jpg?fit=1200%2C1009&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/alejandroescamilla-dude-walkin.jpg?fit=1200%2C1009&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/alejandroescamilla-dude-walkin.jpg?fit=1200%2C1009&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":5996,"url":"https:\/\/herpescureadvocacy.com\/2025\/05\/27\/new-gilead-funded-study-supports-hypothesis-that-hsv-1-significantly-increases-alzheimers-disease-risk\/","url_meta":{"origin":4231,"position":4},"title":"2025 Gilead-Funded Study Supports Hypothesis that HSV-1 Significantly Increases Alzheimer\u2019s Disease Risk","author":"Patient Advocate","date":"May 27, 2025","format":false,"excerpt":"Liu\u00a0Y,\u00a0Johnston\u00a0C,\u00a0Jarousse\u00a0N, et al Association between herpes simplex virus type 1 and the risk of Alzheimer\u2019s disease: a retrospective case\u2013control study BMJ Open\u00a02025;15:e093946.\u00a0doi:\u00a010.1136\/bmjopen-2024-093946 Here are our key takeaways from the study \"Association between herpes simplex virus type 1 and the risk of Alzheimer\u2019s disease: a retrospective case\u2013control study\" published in BMJ\u2026","rel":"","context":"In "Herpes Cure Research"","block_context":{"text":"Herpes Cure Research","link":"https:\/\/herpescureadvocacy.com\/category\/herpes-cure\/"},"img":{"alt_text":"men s white dress shirt","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2025\/05\/pexels-photo-356040-e1748491643899.jpeg?fit=400%2C267&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":247,"url":"https:\/\/herpescureadvocacy.com\/2021\/07\/03\/herpes-and-alzheimers-link\/","url_meta":{"origin":4231,"position":5},"title":"A Herpes and Alzheimer\u2019s link?","author":"Patient Advocate","date":"July 3, 2021","format":false,"excerpt":"There is mounting evidence that has increasingly pointed to HSV-1 as being possibly involved in Alzheimer's disease. Dr. Itzhaki, who has worked extensively to investigate the link, published a paper in 1991 which was the very first experimental study to link HSV1 and AD. In the paper, she noted that\u2026","rel":"","context":"In \"Advocacy\"","block_context":{"text":"Advocacy","link":"https:\/\/herpescureadvocacy.com\/tag\/advocacy\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=1050%2C600 3x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/posts\/4231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/users\/205069572"}],"replies":[{"embeddable":true,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/comments?post=4231"}],"version-history":[{"count":7,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/posts\/4231\/revisions"}],"predecessor-version":[{"id":4239,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/posts\/4231\/revisions\/4239"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/media\/4232"}],"wp:attachment":[{"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/media?parent=4231"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/categories?post=4231"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/herpescureadvocacy.com\/wp-json\/wp\/v2\/tags?post=4231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}