{"id":5996,"date":"2025-05-27T17:58:04","date_gmt":"2025-05-27T21:58:04","guid":{"rendered":"https:\/\/herpescureadvocacy.com\/?p=5996"},"modified":"2026-02-25T17:40:43","modified_gmt":"2026-02-25T22:40:43","slug":"new-gilead-funded-study-supports-hypothesis-that-hsv-1-significantly-increases-alzheimers-disease-risk","status":"publish","type":"post","link":"https:\/\/herpescureadvocacy.com\/2025\/05\/27\/new-gilead-funded-study-supports-hypothesis-that-hsv-1-significantly-increases-alzheimers-disease-risk\/","title":{"rendered":"2025 Gilead-Funded Study Supports Hypothesis that HSV-1 Significantly Increases Alzheimer\u2019s Disease Risk"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Liu\u00a0Y,\u00a0Johnston\u00a0C,\u00a0Jarousse\u00a0N<em>, et al<\/em> Association between herpes simplex virus type 1 and the risk of Alzheimer\u2019s disease: a retrospective case\u2013control study <em>BMJ Open\u00a0<\/em>2025;<strong>15:<\/strong>e093946.\u00a0doi:\u00a010.1136\/bmjopen-2024-093946<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Here are our <strong>key takeaways<\/strong> from the study &#8220;<em>Association between herpes simplex virus type 1 and the risk of Alzheimer\u2019s disease: a retrospective case\u2013control study<\/em>&#8221; published in <em>BMJ Open on May 20, 2025.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>READ STUDY <\/em><a href=\"https:\/\/bmjopen.bmj.com\/content\/15\/5\/e093946\"><em>HERE<\/em><\/a><em>.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Herpes Cure Advocacy<\/em> welcomes the findings of this new retrospective case\u2013control study as further confirmation of the urgent need to elevate herpes simplex virus type 1 (HSV-1) as a public health priority. The study\u2019s conclusion\u2014that HSV-1 infection is significantly associated with an increased risk of Alzheimer\u2019s disease\u2014reinforces growing evidence that chronic viral infections may play a key role in neurodegenerative processes. For decades, HSV-1 has been underestimated and stigmatized, limiting public and scientific discourse. Yet, research like this highlights the virus\u2019s broader systemic implications and the potential for prevention or mitigation through early detection, therapeutic intervention, or even vaccination. This study deepens the case for investing in herpes cure research\u2014not only to address the direct symptoms and stigma of the disease, but also to understand its possible contribution to other health issues such as long-term cognitive decline. It is a call for collaborative, multidisciplinary research that includes the voices of patients and advocates.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\ud83e\udde0 Scientific Implications<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Supports the <strong>viral hypothesis of Alzheimer\u2019s disease<\/strong>, particularly the role of <strong>HSV-1 in neuroinflammation and amyloid-beta plaque formation<\/strong>.<br><\/li>\n\n\n\n<li>Suggests <strong>antiherpetic therapy<\/strong> might be a <strong>preventive strategy<\/strong> for AD in HSV-1 positive patients.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Causality not established<\/strong>\u2014only associations shown.<br><\/li>\n\n\n\n<li>Reinforces the need for <strong>further research<\/strong>, including <strong>prospective studies and mechanistic investigations<\/strong>.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\ud83d\udd2c Study Objective<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Investigate the association between <strong>herpes simplex virus type 1 (HSV-1)<\/strong> and <strong>Alzheimer\u2019s disease (AD)<\/strong> using large-scale U.S. administrative claims data.<br><\/li>\n\n\n\n<li>Assess whether <strong>antiherpetic medications<\/strong> reduce the risk of AD among those diagnosed with HSV-1.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\ud83d\udcca Study Design<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Retrospective matched case\u2013control study<\/strong> using the IQVIA PharMetrics Plus claims database.<br><\/li>\n\n\n\n<li>Included <strong>344,628 matched pairs<\/strong> (AD patients vs. controls), aged \u226550 years.<br><\/li>\n\n\n\n<li>Matched on <strong>age, sex, region, database entry year, and healthcare visit frequency<\/strong>.<br><\/li>\n\n\n\n<li>Analysis also extended to <strong>AD-related dementias (ADRD)<\/strong> and other herpesviruses.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\ud83d\udcc8 Key Findings<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>HSV-1 significantly increases AD risk<\/strong>:<br>\n<ul class=\"wp-block-list\">\n<li>HSV-1 diagnosis was more common in AD patients (0.44%) vs. controls (0.24%).<br><\/li>\n\n\n\n<li>Adjusted odds ratio (OR) = <strong>1.80<\/strong> (95% CI: 1.65 to 1.96), indicating <strong>an 80% increased risk<\/strong> of AD in HSV-1 patients.<br><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Risk increases with age<\/strong>:<br>\n<ul class=\"wp-block-list\">\n<li>Stronger association in older age groups (75+ years: OR = 2.10).<br><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Antiherpetic medication may reduce AD risk<\/strong>:<br>\n<ul class=\"wp-block-list\">\n<li>Among HSV-1 patients, those who took antiherpetic drugs had a <strong>17% lower risk<\/strong> of developing AD.<br><\/li>\n\n\n\n<li>Adjusted hazard ratio (HR) = <strong>0.83<\/strong> (95% CI: 0.74 to 0.92).<br><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Other herpesviruses<\/strong>:<br>\n<ul class=\"wp-block-list\">\n<li><strong>HSV-2 and VZV<\/strong> were also associated with increased AD risk.<br><\/li>\n\n\n\n<li><strong>CMV<\/strong> showed no significant association.<br><\/li>\n\n\n\n<li><strong>COPD<\/strong> (a non-infectious comparator) was more common in controls.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u26a0\ufe0f Study Limitations<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Asymptomatic HSV-1 infections<\/strong> likely underreported.<br><\/li>\n\n\n\n<li>Possible <strong>diagnosis misclassification<\/strong> for both HSV and early AD.<br><\/li>\n\n\n\n<li>Claims data may miss <strong>older adults (65+)<\/strong> covered by Medicare.<br><\/li>\n\n\n\n<li><strong>Importantly,<\/strong><strong> causality is not established<\/strong>\u2014only associations shown.<br><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">NOTE: As of May 2025, Gilead is supporting two Phase 1 clinical trials for two different antiviral therapies.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Disclaimer: This post was drafted by the HCA team with the support of ChatGPT. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liu\u00a0Y,\u00a0Johnston\u00a0C,\u00a0Jarousse\u00a0N, et al Association between herpes simplex virus type 1 and the risk of Alzheimer\u2019s disease: a retrospective case\u2013control study BMJ Open\u00a02025;15:e093946.\u00a0doi:\u00a010.1136\/bmjopen-2024-093946 Here are our key takeaways from the study<a class=\"more-link\" href=\"https:\/\/herpescureadvocacy.com\/2025\/05\/27\/new-gilead-funded-study-supports-hypothesis-that-hsv-1-significantly-increases-alzheimers-disease-risk\/\">Continue reading <span class=\"screen-reader-text\">&#8220;2025 Gilead-Funded Study Supports Hypothesis that HSV-1 Significantly Increases Alzheimer\u2019s Disease Risk&#8221;<\/span><\/a><\/p>\n","protected":false},"author":205069572,"featured_media":5998,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[2871573],"tags":[],"class_list":["post-5996","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-herpes-cure","entry"],"yoast_head":"<!-- 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Alzheimer\u2019s, a progressive neurological disorder, is the most common cause of dementia worldwide, while HSV is best known for causing cold sores and genital\u2026","rel":"","context":"In &quot;Herpes Basics&quot;","block_context":{"text":"Herpes Basics","link":"https:\/\/herpescureadvocacy.com\/category\/article\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":261,"url":"https:\/\/herpescureadvocacy.com\/2021\/07\/08\/herpes-is-not-benign-nine-health-complications-linked-to-hsv\/","url_meta":{"origin":5996,"position":1},"title":"Herpes is not Benign: Nine health complications linked to HSV","author":"Patient Advocate","date":"July 8, 2021","format":false,"excerpt":"This post is for anyone supporting the narrative about Herpes Simplex Virus that \u201cit\u2019s not a big deal\u201d. This is to encourage NIH for more urgency for treatment research, cure, and serology testing. This is to urge the CDC to develop a real prevention strategy including testing and tracking. Herpes\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/alejandroescamilla-dude-walkin.jpg?fit=1200%2C1009&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/alejandroescamilla-dude-walkin.jpg?fit=1200%2C1009&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/alejandroescamilla-dude-walkin.jpg?fit=1200%2C1009&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/alejandroescamilla-dude-walkin.jpg?fit=1200%2C1009&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/alejandroescamilla-dude-walkin.jpg?fit=1200%2C1009&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":247,"url":"https:\/\/herpescureadvocacy.com\/2021\/07\/03\/herpes-and-alzheimers-link\/","url_meta":{"origin":5996,"position":2},"title":"A Herpes and Alzheimer\u2019s link?","author":"Patient Advocate","date":"July 3, 2021","format":false,"excerpt":"There is mounting evidence that has increasingly pointed to HSV-1 as being possibly involved in Alzheimer's disease. Dr. Itzhaki, who has worked extensively to investigate the link, published a paper in 1991 which was the very first experimental study to link HSV1 and AD. In the paper, she noted that\u2026","rel":"","context":"In \"Advocacy\"","block_context":{"text":"Advocacy","link":"https:\/\/herpescureadvocacy.com\/tag\/advocacy\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=700%2C400 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2021\/07\/old-450742_1280-1.jpg?fit=1200%2C1118&ssl=1&resize=1050%2C600 3x"},"classes":[]},{"id":4231,"url":"https:\/\/herpescureadvocacy.com\/2024\/08\/03\/herpes-impact-on-brain-health-new-study-indicates-shringix-vaccine-prevents-dementia\/","url_meta":{"origin":5996,"position":3},"title":"Herpes Impact on Brain Health: New study indicates Shringix Vaccine prevents dementia","author":"Patient Advocate","date":"August 3, 2024","format":false,"excerpt":"Experts insist we are at a tipping point in scientific research relating to herpesviruses impact on dementia and Alzheimer's Disease. Last month a new study from a team in Australia indicated that vaccination against Varicella Zoster (VZV) with the Shingles vaccine was found to be preventative against dementia. Read this\u2026","rel":"","context":"In &quot;Herpes Cure Research&quot;","block_context":{"text":"Herpes Cure Research","link":"https:\/\/herpescureadvocacy.com\/category\/herpes-cure\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2239,"url":"https:\/\/herpescureadvocacy.com\/2023\/04\/24\/nih-forms-multi-council-working-group-for-herpes\/","url_meta":{"origin":5996,"position":4},"title":"NIH forms Multi-Council Working Group for Herpes","author":"Patient Advocate","date":"April 24, 2023","format":false,"excerpt":"Herpes Cure Advocacy celebrates a step forward on the path to the cure, treatment and prevention of Herpes. NIH has assembled a Multi-Council Working Group for Herpes Simplex Virus and are calling for input from field scientists and the general public. Herpes patients and field experts are excited to see\u2026","rel":"","context":"Similar post","block_context":{"text":"Similar post","link":""},"img":{"alt_text":"person holding laboratory flask","src":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/pexels-photo-2280571.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/pexels-photo-2280571.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/pexels-photo-2280571.jpeg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/pexels-photo-2280571.jpeg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/pexels-photo-2280571.jpeg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/herpescureadvocacy.com\/wp-content\/uploads\/2023\/04\/pexels-photo-2280571.jpeg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":1300,"url":"https:\/\/herpescureadvocacy.com\/2022\/06\/30\/important-win-for-herpes-advocacy-fy-2023-congress-budget-update\/","url_meta":{"origin":5996,"position":5},"title":"Important Win for Herpes Advocacy: FY 2023 Congress Budget Update","author":"Patient Advocate","date":"June 30, 2022","format":false,"excerpt":"Herpes Cure Advocacy celebrates and thanks the US House of Representatives for their prioritization of federal action for Herpes Simplex Virus cure, treatment and prevention in the FY 2023 House budget report. 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